产品货号：
Z25000
中文名称：
RALB抗体
英文名称：
Anti-RALB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RALB Antibody |
| 指标别名 | RALB;Ras related protein Ral B |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ICC/IF,FCM |
| 基因名称 | RALB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human RALB (166-203aa DKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERC),different from the related mouse sequence by three amino acids,and from the related rat sequence by four amino acids. |
| 实际分子量 | 23KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the RALB gene on chromosome 2.This protein is one of two isoforms of the Ral protein,the other being RalA,and part of the Ras GTPase family.As a Ras GTPase,RalB functions as a molecular switch that becomes active when bound to GTP and inactive when bound to GDP.RalB can be activated by RalGEFs and,in turn,activate effectors in signal transduction pathways leading to biological outcomes.Additionally,Ral proteins have been associated with the progression of several cancers,including bladder cancer and prostate cancer.While the above functions appear to be shared between the two Ral isoforms,their differential subcellular localizations result in their differing involvement in certain biological processes.In particular,RalB is more involved in apoptosis and cell motility.Moreover,RalB specifically interacts with Exo84 to assemble the beclin-1–VPS34 autophagy initiation complex,and with Sec5 to activate the innate immune response via the Tank-binding kinase 1 (TBK1). |
| Uniprot ID | P11234 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | v-ral simian leukemia viral oncogene homolog B |
| 蛋白名全称 | Ras-related protein Ral-B |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells |
相关搜索：RALB抗体，RALB多抗，Anti-RALB Antibody